In this trial we are looking to measure and objectively quantify the severity of motor symptoms of Parkinson's and to continuously monitor those symptoms. The objective of phase two of the trial will be to monitor any changes or fluctuations in symptom severity and presentation in remote assessment. Identifying the fluctuations and symptom severity will go a long a long way in supporting patients in reporting their symptoms more accurately and allow clinicians an objective and continuous observation of each patient outside of what they would see in a standard Universal Parkinson's Disease Rating Scale (UPDRS) assessment.

This is an industrial research project in which SERG, in partnership with chartered neurological physiotherapists from the LV Rehabilitation Centre and the Neuromuscular Rehabilitation Technology Network at Imperial College London, will develop the first closed-loop, at-home, rehabilitation platform for Parkinson's Disease and wider neurological disorders.

The aim of this trial is to take the SERG PD.Ignite Ecosystem developed through the course of the preceding trials and generate the evidence of accuracy and effectiveness for the exploration of how to certify and bring the ecosystem to market.

This trial is intended to demonstrate the accuracy, utility and reliability of the SERG-UPDRS scale, a continuous alternative to the existing MDS-Universal Parkinson’s Disease Rating Scale (MDS-UPDRS). MDS-UPDRS allows a clinician to quickly categorise a patients symptom severity by a quick visual inspection, however, it has two major challenges which the trial looks to mitigate:
1) The categories are defined objectively but rely on a clinician's perception to perform categorisation.
2) The categories are broad and provide no way of evaluating subtle changes within categories.

This project aims to develop and clinically test a simple wearable armband that senses and suppresses tremor by delivering tiny electrical stimulation (ES), which is not felt by the wearer, to the forearm or wrist. The armband may be worn indefinitely, thus offering the potential for constant tremor suppression. The team has already developed constituent elements of the system and proven their ability to sense and suppress tremor. This study has the potential to replace and/or complement current tremor treatment, eliminate side effects, and improve quality of life for a very large patient population.